Extensive mucinous eccrine naevus following the lines of Blaschko: a new type of eccrine naevus.
نویسندگان
چکیده
A 32-year-old woman had several brownish and pruritic lesions over her left buttock and leg that had been present since she was 12 years old. She observed a progressive increase in size and number of the lesions, with increased sweating on and around them. Examination revealed several brownish, irregular nodules, 1–1.5 cm in diameter, and firm to palpation, along the lower left limb and following the lines of Blaschko (Fig. 1a–c). Iodine starch method showed increased sweating localized on the nodules. We made an excisional biopsy of one brownish nodule and of the contralateral nonaffected location. The number of ducts and secretory coils showed a mean of 28 elements in hamartomatous glands, and seven elements in the contralateral normal limb (each secretory coil or duct is considered an element) (Fig. 2a,b). The number of units of sweat glands was increased by around 40%. Also, the hamartomatous glands showed an eccrine gland of diameter 2.4 mm against 0.2 mm in the normal glands, and an eccrine secretory coil diameter in cross-sections of the hamartomatous gland of 160 pm vs. 75 μm in the normal eccrine glands. Abundant mucinous material around sweat glands stained strongly with Alcian blue, pH 2.5. The vessels in the connective tissue close to the hamartomatous gland were thicker than the same anatomical vessels in the normal glands. The arrector pili muscle appeared enlarged in the skin of the hamatomatous glands in contrast to the same structure in the reference skin (395-μm diameter in crosssections vs. 170 μm in normal muscle).
منابع مشابه
Porokeratotic eccrine ostial and dermal duct nevus with extensive linear distribution: a case report
Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is known as an uncommon disorder of keratinization in which acrosyringium is involved; however, its causes have yet remained unknown. It is presented clinically by discrete keratotic papules on distal extremities arranged in a linear pattern along Blaschko lines. Histopathologically, it is characterized by cornoid lamella, which is alm...
متن کاملEfficacy of botulinum toxin for a congenital eccrine naevus.
Editor Congenital eccrine naevus is a rare clinical entity. Fewer than 20 cases had been reported, and only three cases were congenital. 1,2 We present a child with congenital localized hyperhidrosis on the forearm. To the best of our knowledge, this is the first congenital eccrine naevus successfully treated with botulinum toxin type A. A 12-year-old girl with no significant past medical histo...
متن کاملLong-term involution of unilateral porokeratotic eccrine ostial and dermal duct naevus.
Sir, Porokeratotic eccrine ostial and dermal duct naevus (PEODDN) is a rare disorder of keratinization with eccrine involvement that histologically presents a cornoid lamella exclusively associated with eccrine ostia and the underlying sweat ducts (1). It is an expression of genetic mosaicism (2) and is characterized by asymptomatic grouped keratotic papules and plaques with a linear distributi...
متن کاملTubular spitz naevus mimicking eccrine spiradenoma.
© 2014 The Authors. doi: 10.2340/00015555-1641 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Spitz naevus was first described by Sophie Spitz in 1948 (1). It is a variant of benign melanocytic naevus composed of spindled and epithelioid melanocytes, found predominantly in children and adolescents. A number of histopathological variants have been reported, such as desmopl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The British journal of dermatology
دوره 154 5 شماره
صفحات -
تاریخ انتشار 2006